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Photo courtesy: Will Kirk
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Oct 2007 onwards |
Scientist, National Institute of Immunology (Oct 2007 onwards)
Ramalingaswami Fellowship
of the Department of Biotechnology |
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Post doctoral fellowships |
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| 2003-2007 |
Prof. K. J. Yarema, Johns Hopkins University (JHU), Baltimore MD
USA.
https://jshare.johnshopkins.edu/kyarema1/public_html/
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2000-2003 |
Dr. V. Pozsgay, National Institutes of Health (NIH),
Bethesda
MD
USA.
http://dir2.nichd.nih.gov/dirweb/people.do?id=12&abbrev=LDMI&level=lab&detail=list
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1998-1999 |
Prof. Dr. A. Vasella, Eidgenössische Technische Hochschule (ETH),
Zürich Switzerland.
http://avws-indi2.ethz.ch/ |
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1998 |
Ph. D., Prof. S. Chandrasekhar, Indian Institute of Science (IISc),
Bangalore
http://www.orgchem.iisc.ernet.in/ |
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1991 |
M.Sc., and B.M.
Sc., RKM
Vivekananda
College,
Univ. of Madras, Chennai
http://www.viveka.org/chemistry.htm |
Research Interests and
Goals
We are interested in the
study of the significance and role of glycoconjugates – which
include glycoproteins (GP), glycolipids (GL), glycosaminoglycans (GAG),
and glycosylphosphatidyl inositol (GPI) anchors, and bacterial-derived
capsular polysaccharides (CPS), lipopolysaccharides (LPS), peptidoglycans
(PG) – in fundamental biological and immunological processes using the
tools of chemical biology, in an interdisciplinary manner. The past decade
has seen rapid growth in the realization and understanding of the
importance of glycans and glycoforms in various biological processes
(homeostasis, development, disease states, and differentiation) and their
importance in biopharmaceuticals. We seek to apply the power of modern
synthetic carbohydrate chemistry to (i) study cellular systems, and
develop (ii) inhibitors, mimics and drugs, (iii) novel tools for ‘glycomics’,
and (iv) synthetic oligosaccharide-based conjugate vaccines.
Our current projects
involve study of (a) glycosylation pathways in the central nervous system
(CNS), (b) role of glycoconjugates in cancer metastasis, (c) the
importance of glycoforms in definition of human cell differentiation
molecules (HCDM). We are looking for student trainees, project assistants
and associates on a continuous basis. If interested, please send in your
curriculum vitae to
gopalan@nii.res.in .
Selected
Publications
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Campbell, C. T., Sampathkumar, S.-G., and Yarema, K. J. (2007).
Metabolic Oligosaccharide Engineering: Perspectives, Applications, and
Future Directions. Mol. Biosyst. 3, 187-194.
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Sampathkumar,
S.-G., Jones, M. B., Meledeo, M. A., Campbell, C. T., Choi, S. S., Hida,
K., Gomutputra, P., Sheh, T., Gilmartin, T., Head, S. R., and Yarema, K.
J. (2006). Targeting glycosylation pathways and the cell
cycle: Sugar-dependent activity of butyrate-carbohydrate cancer prodrugs.
Chem. Biol. 13, 1265-1275.
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Sampathkumar
S.-G., Li, A. V., Jones, M. B., Sun, Z., and Yarema K. J.
(2006). Metabolic installation of thiols into sialic acid modulates
adhesion and stem cell biology. Nat. Chem. Biol. 2, 149-152.
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Pozsgay,
V., Ekborg, G., and Sampathkumar, S.-G. (2006). Synthesis of hexa- to
tridecasaccharides related to Shigella dysenteriae type 1 for
incorporation in experimental vaccines. Carbohydr. Res. 341,
1408-1427.
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