A Program for Detection
and Analysis of Polyketide Synthase Domains
Gitanjali Yadav,
Rajesh S. Gokhale and Debasisa Mohanty
National Institute
of Immunology
New Delhi-110067
India
SEARCHPKS is a software
for detection and analysis of Polyketide
Synthase domains.
This program facilitates easy identification of various PKS
domains and modules from a given polypeptide sequence. In addition it predicts the specificity of
the potential acyl transferase
domains for various
starter and extender precursor units. SEARCHPKS
is a user-friendly tool for correlating polyketide
chemical structures with the organization of domains
and modules in the corresponding modular polyketide synthases. This program also allows the user to extensively analyze and assess the sequence homology
of various polyketide synthase domains providing guidelines for carrying
out domain and module
swapping experiments.
The computational approach used in SEARCHPKS is based on a comprehensive analysis of various
characterized clusters of modular
polyketide synthases, compiled in PKSDB.
