Dr. Satyajit Rath

Our current projects are examining APCs and pathways involved in antigen presentation to MHC class I and class II-restricted T cells, and analysing the consequences of intracellular signal transduction modulation for both development and responses of T cells and myeloid cells using genetic as well as pharmacological tools. Here below are a few ongoing examples, along with the group members and collaborators involved in them.

In one approach, we are trying to elucidate the unique roles that individual death pathways play at different stages of the development and functioning of T and B cells.
(Shalini Tanwar, Jasneet Kaur Khalsa and Atika Dhar, in collaboration with Anna George and Vineeta Bal at NII, Apurva Sarin at NCBS, Bangalore, India, and Jeannine Durdik at the University of Arkansas, Fayetteville, USA)

In a second approach, we are trying to understand how the dynamics of MHC and T cell receptor molecules on interacting T cells and APCs are controlled, and how these controls regulate the functional responses of T cells.
(Renu Balyan in collaboration with Anna George and Vineeta Bal at NII, and Satyajit Mayor at NCBS, Bangalore, India)

In a third approach, we are dissecting the roles of quantitative modifiers of immune signal transduction pathways, ranging from proteasomal components to tyrosine kinases, in controlling the development and functioning of myeloid and lymphoid cells.
(Shalini Tanwar and Amanpreet Singh Çhawla in collaboration with Anna George and Vineeta Bal at NII, and Savit Prabhu at PBC-THSTI, Delhi-NCR)

In a fourth approach, we are characterising the diversity and stability of immunocyte subpopulation phenotypes in human peripheral blood and their correlation with various states of immune dysfunction in neonates. (Amanpreet Singh Chawla in collaboration with Anna George and Vineeta Bal at NII, Savit Prabhu, Uma Chandra Mouli Natchu, Nitya Wadhwa and Shinjini Bhatnagar at PBC-THSTI, Delhi-NCR, and Ranjan Sen at the NIA-NIH, Baltimore, USA)

In a fifth approach, we are examining the immunogenetic basis of autoimmune responses to complement components and their contribution to human disease (Bahadur Singh Gurjar in collaboration with Anna George and Vineeta Bal at NII, Savit Prabhu, Uma Chandra Mouli Natchu, Nitya Wadhwa and Shinjini Bhatnagar at THSTI, Gurgaon, Arvind Bagga at AIIMS, New Delhi, Priyadarshni Chatterjee at RCB, Delhi-NCR, and Arvind Sahu at NCCS, Pune)