Dr. Devram Ghorpade

The basic idea of our research is based on the fact that nothing works in isolation and in the functioning of a body the integrative cross-talk among multi-organs is a must. We trust in the amazing capacity of the body to adjust to the insults/adverse conditions to maintain homeostasis. So far, the role of individual organs or cells has been the major focus of research. However, the detailsof how multiorgan’scommunicate and maintain homeostasis arelargely unknown. Thus, there exists a tremendous scope to learnand discover novel processes. Here at NII, our laboratory is actively involved in understanding such communication processes among multi-organs using the mouse genetic models of obesity and associated metabolic diseases like diabetes, inflammatory bowel diseases, etc.

Broadly, our group is involved in learning about the following areas:

1. How do multi-organs communicate in high-fat diet-induced metabolic disorders like diabetes and inflammatory bowel diseases?

2. What are the messenger molecules (biofactors and/or hormones) that effectuate metabolic homeostasis?

3. Could organ-specific targeting be established as a better therapeutic platform for metabolic diseases?

Patents:
1. Dipeptidyl Peptidase-IV (DPP4) Inhibitors, Methods, and Compositions for Suppressing Adipose Tissue Inflammation, Dr. Ira Tabas, Dr. Devram Sampat Ghorpade, Dr. LaleOzcan, U.S. Provisional Patent Application No:62/120,549, 2015.